GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THYM | cis | rs9309473 | 1 | rs6740223 | chr2:73653332 | ALMS1P | chr2:73872046-73912692:+ | 0.58 | 4.7 | 8.77E-6 | Metabolite levels |
| THYM | cis | rs4663866 | 1 | rs6741269 | chr2:239179418 | LOC151174 | chr2:239133754-239140318:- | 0.93 | 4.57 | 1.47E-5 | Irritable bowel syndrome |
| THYM | cis | rs6545883 | 1 | rs6742276 | chr2:61768745 | AHSA2 | chr2:61404553-61414058:+ | -0.48 | -5.94 | 4.71E-8 | Tuberculosis |
| THYM | cis | rs6545883 | 1 | rs6742276 | chr2:61768745 | C2orf74 | chr2:61372243-61391964:+ | 0.58 | 7.39 | 5.81E-11 | Tuberculosis |
| THYM | cis | rs9309473 | 1 | rs6745368 | chr2:73809974 | ALMS1P | chr2:73872046-73912692:+ | 0.59 | 4.56 | 1.53E-5 | Metabolite levels |
| THYM | cis | rs12780845 | 1 | rs67505314 | chr10:17240134 | CUBN | chr10:16865966-17171816:- | 0.3 | 4.64 | 1.12E-5 | Homocysteine levels |
| THYM | cis | rs3820928 | 1 | rs6752707 | chr2:227766822 | RHBDD1 | chr2:227700773-227861591:+ | -0.31 | -4.56 | 1.51E-5 | Pulmonary function |
| THYM | cis | rs9309473 | 1 | rs6753344 | chr2:73653138 | ALMS1P | chr2:73872046-73912692:+ | -0.59 | -4.56 | 1.53E-5 | Metabolite levels |
| THYM | cis | rs2243480 | 1 | rs67536397 | chr7:65947917 | CCT6P1 | chr7:65216092-65228661:+ | 0.6 | 4.86 | 4.72E-6 | Diabetic kidney disease |
| THYM | cis | rs9309473 | 1 | rs6755217 | chr2:73641285 | ALMS1P | chr2:73872046-73912692:+ | 0.64 | 4.66 | 1.02E-5 | Metabolite levels |
| THYM | cis | rs9309473 | 1 | rs6755241 | chr2:73641364 | ALMS1P | chr2:73872046-73912692:+ | 0.62 | 4.46 | 2.21E-5 | Metabolite levels |
| THYM | cis | rs911119 | 1 | rs67567111 | chr20:23619075 | CST9 | chr20:23583049-23586610:- | -0.48 | -4.46 | 2.25E-5 | Chronic kidney disease |
| THYM | cis | rs9309473 | 1 | rs6756987 | chr2:73687077 | ALMS1P | chr2:73872046-73912692:+ | 0.58 | 4.72 | 8.0E-6 | Metabolite levels |
| THYM | cis | rs6759004 | 1 | rs6759004 | chr2:202004676 | CFLAR | chr2:201980816-202029001:+ | -0.39 | -5.7 | 1.33E-7 | Triptolide cytotoxicity |
| THYM | cis | rs6759004 | 1 | rs6759004 | chr2:202004676 | PPIL3 | chr2:201735680-201753999:- | -0.86 | -8.94 | 3.12E-14 | Triptolide cytotoxicity |